"Abusers of themselves with mankind" primarily refers to homosexuality & paedophilia. One could also look at the verse as a person abusing their God-appointed gender & its appropriate behaviour by choosing to act in ways contrary to proper manner. You will notice that "effeminate" is also included in that list & probably does not have the same meaning as we know it today, but to "sensuality & corrupt indulgences" which might have inferred crossing the gender boundaries & which was common in the Greek world.
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