From a derivative probably of paio (meaning a "path"); to trample (literally or figuratively) -- tread (down, under foot).
see GREEK paio
b. to advance by setting foot upon, tread upon: ἐπάνω ὄφεων καί σκορπίων καί ἐπί πᾶσαν τήν δύναμιν τοῦ ἐχθροῦ, to encounter successfully the greatest perils from the machinations and persecutions with which Satan would fain thwart the preaching of the gospel, Luke 10:19 (cf. Psalm 90:13 c. to tread underfoot, trample on, i. e. treat with insult and contempt: to desecrate the holy city by devastation and outrage, Luke 21:24; Revelation 11:2 (from Daniel 8:13); see καταπατέω. (Compare: καταπατέω, περιπατέω, ἐμπεριπατέω