Superlative from the base of hupsos; highest, i.e. (masculine singular) the Supreme (God), or (neuter plural) the heavens -- most high, highest.
see GREEK hupsos
a. of place: neuter τά ὑψιστα (the Sept. for מְרומִים), the highest regions, i. e. heaven (see ὑψηλός, a.), Matthew 21:9; Mark 11:10; Luke 2:14; Luke 19:38, (Job 16:19; Isaiah 57:15).
b. of rank: of God, ὁ Θεός ὁ ὕψιστος, the most high God, Mark 5:7; Luke 8:28; Acts 16:17; Hebrews 7:1; (Genesis 14:18; Philo de leg. ad Gaium § 23); and simply ὁ ὕψιστος, the Most High, Acts 7:48; mid without the article (cf. Buttmann, § 124, 8 b. note; (WH. Introductory § 416)), Luke 1:32, 35, 76; Luke 6:35, and very often in Sir.; (Hebrew אֶלְיון, עֶלְיון אֵל, עֶלְיון אֱלֹהִים, עֶליון יְהוָה; Ζεύς ὕψιστος, Pindar Nem. 1, 90; 11, 2; Aeschylus Eum. 28).